Lipophilic Detoxification

 

A dietary strategy for detoxification of fat-soluble toxins including Agent Orange, Dioxin, & DDT.

 

 

Whole Health Research Alliance
mark.squibb@wholehealthnetwork.com


Lipophilic Toxins

Your body is made by cells.  Molecular fats or lipids are essential to cell biology and structure.  Most, if not all essential cellular structures rely on lipids for some aspect of function or structure.  Lipids and water are the chemical basis of human life.

Lipos is Greek for fat.  Over the past fifty or so years widespread and deceptive, and defamatory information regarding the bio-essential lipids has been pervasive in popular media and medical culture.  People have become afraid of dietary fat often with serious results.  Fat is a huge topic, and we’re only going to talk about a small area of lipid chemistry.

There are two general kinds of toxin identified by their solubility.  Solubility is a result of molecular electrical properties that derive from the chemical structure:

Contrary to popular belief, our bodies are able to dispose of lipophilic toxins under the appropriate conditions.  Unfortunately due to widespread lipo-phobia, these conditions are unpopular in medical dogma, popular press and fad-diet literature.

DDT, Dioxin, and Agent Orange are lipophilic toxins.  They pollute the lipids or fats in your body and make you sick.  Toxins stored in fats are difficult to release.  Most treatments make symptoms worse. 

Our use of term lipophilic toxin throughout this document, refers to a the a spectrum of toxins including Dioxin, Agent Orange, and all of the Agent colors used during the Viet Nam war as defoliants.  Generally these toxins share a chemical structure of two benzene rings, chlorine molecules on the end with oxygen molecules between the benzene rings.

 

Since plants have much less fat than humans, a very small amount of lipophilic toxin is fatal to plants because a small amount of poison fatally damages the plant’s metabolism.  This is why they are effective defoliants and kill plants more quickly than animals.

Detoxification

Physiologically, our bodies are designed to dispose of damaging chemicals.  Generally these molecules are toxins.  There are many.

Lipophilic toxins pollute the lipid system.  The liver, the largest organ in your body which lies underneath the lower rib cage, from the right armpit across the back, is responsible for selecting friend and foe for every molecule circulating in your body.

If you look at the word liver, it’s root is the word “live”.  The spelling is neither accident nor joke.  When you liver is sick, you are too.

The liver is able to regenerate after 75% destruction.  This is wonderful because it means that many people can recover and live normal lives after their liver recovers.  The trick is to establish the bio-metabolic conditions to re-establish normal liver function.

In the case of lipophilic poisons – this isn’t easy.  Lipophilic poisons run in a closed circuit. 

The liver’s job is to dump toxins.  The liver is made of mostly fat. Fat loving toxins quickly re-enter fat, so when the liver releases a lipophilic toxin, the liver itself becomes polluted.

The normal outcome is a sick liver, and diminished liver function.  There is a very popular list of liver related illnesses, including diabetes, heart disease, cancer and so on.  Most, if not all of these diseases, have immunological and toxicological cofactors.  Basically, if you liver is working well, you won’t have a serious disease. 

Lipophilic detoxification is really tricky because the body and liver do a good job of lipid recycling.

Biological Strategy

The lipophilic detoxification strategy uses some very basic chemistry – and works like changing the oil in your car.

The model is simple.  Think about the oil in your car’s engine.  When the oil is dirty, you change it, replacing dirty oil with fresh.  The old dirty oil is drained and discarded.  If you put a cup of dioxin in your car’s engine, and changed the oil, very little dioxin would remain after even a single oil change.  

The human body is different.  You can’t drain the oil.  Lipophilic cleansing gradually replaces the cellular lipids by over-supplying ideal lipids.  It is like adding a little fresh oil to your car every day, and letting the over-flow escape to dispose of the dirty oil.  The oil gets cleaner, just not all at once. 

About 80% of the food-components that enters your body go to the liver first.  The portal vein traverses the gut and collects food from the intestines.  The portal vein splits and about 80% of the portal blood flow to the liver.  This means that 80% of everything you eat goes directly to the liver.

The liver produces bile.  Bile is soap.  Bile soap is made of used-up fats or lipids mixed with bile salts.  Bile salts are heavily alkali materials.  Your bathroom soap is a mixture of fat and alkali salts.  Soap is a surfactant and it dissolves up fats. 

Eating fat causes your liver to release bile, which is made of fat, to dissolve the fat that you ate.  The gut, small and large intestine, choose which fats to reabsorb.  Excess fat is not absorbed, and is passed in the stool.   Some lipids are released through the skin also.

Lipophilic cleansing is a three part problem:

1.      Get the liver to release lipophilic toxins into the bile;

2.      Trigger the bile release so the lipophilic toxins reach the gut;

3.      Prevent the lipophilic toxins from being re-absorbed.

In American lifestyle, these essential conditions rarely exist together.  As a result the body rarely, if ever, gets the chance to release lipophilic toxins.

The Phospholipid Key

There is a special class of molecules are called phospholipids.  These molecules are special because they are bio-identical to cell membranes.  The cell membrane is the exterior coating of the cell.  When a phospholipid capsule touches a cell membrane, the capsule is integrated into the cell wall, or adsorbed. 

The therapeutic key to phospholipids nutrients is that they have nearly 100% cellular integration.  This means that dietary phospholipids are almost guaranteed to become part of a cell.  Indirectly this means that they will dilute cellular lipids, and consequently any toxins resident inside those lipids.

Moreover, most ingested of phospholipids go directly to the liver, and integrate with liver cells diluting toxins where dilution is most needed.   In other words phospholipids deliver the perfect stuff exactly where it’s needed.

Physiologically, phospholipids enter the bloodstream without digestion.  Since they don’t require digestion, and enter cells directly, they are ideal for supporting lipid dilution, and consequently lipid-toxin dilution:

·         Direct delivery of unpolluted lipids to the cells enabling controlled dilution of polluted cellular lipids;

·         Direct delivery of anti-oxidants to the cellular material, particularly the ability deliver therapeutic quantities of glutathione, an anti-oxidant usually damaged by digestion to the liver.

Lipid Turnover

Most cells in the body, excepting adipose tissue and beta-oxidation dominant cells, maintain lipid balance by various forms of ongoing lipid exchange.  This means that when cells absorb lipids, they will release an equivalent amount in order maintain lipid balance.   There are several forms of lipid turnover:

·         Cell turnover.  When healthy cells divide, they grow themselves by absorbing nutrients.  Existing lipids are retained, and new ones are absorbed until the cell splits.  In an environment rich in unpolluted nutrients, the embedded toxicity in the original cell is diluted by the clean nutrients that integrate into the daughter cells;

·         Lipid Exchange.  Non-dividing cells absorb and release lipids as part of the metabolic exchange.  The released lipids generally contain some lipophilic toxins depending on the ability of the toxin to escape the outgoing lipid;

·         Dermal, skin, release.  Oily skin and hair are a result of the topical release of lipids.  Dermal excretion of lipids serves to lubricate and protect the skin and serves as a backup exit path for excess lipids.

Phospholipids participate heavily in both processes.  In the case of cell turnover, clean building materials make for cleaner daughter cells.  In the case of lipid exchange, the cells lipids are diluted by the new clean phospholipids.

Lipophilic Toxins and Energy Metabolism

Physiologically lipids are building materials and an energy source.  Use of polluted lipids for energy metabolism disrupts essential cell functions and causes other health issues.

Cellular mitochondria use a combination of sugars and fat, depending on the specifics of the cell and the metabolic factors.  The fat to energy pathway is called the Beta-Oxidation pathway.   The sugar energy pathway is called the citric acid cycle.  Generally the body uses both of these pathways for cellular energy production.

The Beta-Oxidation pathway uses fat for cellular energy.  The unfortunate result of converting fat from lipid to CO2 and H2O, frees the solute lipophilic toxins to relocate from it’s modestly-harmful lipid-bound home to mitochondrial lipid structures, permanently damaging the cellular energy factory, or to other essential cellular lipid structures within the cell.

Detox-Retox Disaster

In other words burning fat aggravates the lipophilic toxin problem.  This pattern is prime cofactor in the rotating pattern of cellular dysfunctions for individuals exposed to lipophilic toxins.

Do not use regular detoxification to treat lipophilic toxicity.  Over activation of the Beta-Oxidation pathway causes severe illness for lipophilic toxicity.  

Relocation of lipophilic toxins from non-essential fuel fats to essential cell structures is a recipe for disaster.  While a few people may have hearty enough elimination systems to successfully detoxify, they are the strong minority, and probably didn’t get sick in the first place. 

In other words… Don’t try an off the shelf detoxification program for lipophilic toxins.

Releasing toxins that have no place to go is in invitation for disaster.  This phenomenon explains why:

·         Individuals who use normally successful detoxification protocols get so sick that they have to abandon the program;

·         Detox strategies haven’t become standard treatment for lipophilic toxicity disorders.

Mitochondrial dysfunction driven by recycled lipophilic toxins is a probable culprit in a wide range of symptoms of individuals suffering from lipophilic toxicity. 

The Journal

Pay attention to the way you feel.  Curiously a record, either with pencil and paper, or computer is the most powerful medical diagnostic tool known to man. 

A written record is very important because humans are unable to remember pain.  You can remember you felt lousy, but you will not be able to remember qualitatively how poorly you felt at an earlier time.

Journaling also lets you identify trends.  This program is designed to be gradual.  This means that your health changes will occur over a period of weeks or months.  It is very unlikely that you’ll wake up one morning and feel great.  Generally you will start a trend of feeling less poorly than you did yesterday. 

Quantitively assigning numbers to the way you feel “now” will create a reasonably objective ongoing record.  When you look back two months, it will be generally apparent whether you’ve made progress, or not.

Here is a link to a spreadsheet to help with journaling.

A camera is also very helpful.  Take a picture of yourself your face before you start.  The eyes, skin color, skin tone are very useful telltales for system toxicity.  Dark circles under the eyes, yellow whites, dull eye sheen, and skin tone all reflect vitality.

A before/after picture can say a thousand words about whether your health is improving.

Skin pruning is another helpful telltale.  Since liver toxicity often results in systemic sterol deficiency, the skin often lacks the ability to resist water.  Take a long hot bath and note how long it takes for your fingers to prune up.  The longer pruning takes, the more healthy your skin. 

Fat versus Fiction

Most people will lose weight with this program. 

The nutrition program is very similar to the Atkins Eating program, widely credited with significant gain loss for many people,.  The principle of the Atkins program is the displacement of carbohydrates with nutrient dense foods, particularly protein.  The normal result of a nutrient dense high fat diet is weight loss.   This program emphasizes high quality lipids in place of proteins.

This program is exactly opposite of the anti-fat diets, and cardiology dogma of the last several decades. 

Surprisingly a high fat, balanced diet often helps to normalized cholesterol and triglycerides levels, and helps prevent heart disease.

The Reasons for Fat and Carbohydrate

This program balances carbohydrates with fats intake.  The eating includes both fat and carbohydrates to support normal cellular energy production with three goals:

Digestion is Critical

Many people suffer from dysfunctional digestion.  Telltales for digestive insufficiency:

It is very important to reestablish normal digestion during this process.  The eating program naturally provides raw materials for natural digestion.  Unfortunately, this doesn’t mean that you will automatically get good digestion by following the eating program.

Weekly Shopping List

Detoxification begins at the grocery store.   This is the approximate weekly amount of high-lipid foods.  Please note that this is a lot of food.  This is a CALORE-ENHANCED eating program – not a diet.

Fish and seafood are okay to eat too, as long as the meal includes an adequate amount of butter, cream or other fat.

Note that major items are very high in fat.

Grocery Item

Amount

Supplies

Notes

Butter

2 pounds

Supplies butyrate and good quality sterols.

 

Eggs

2 dozen

Natural source of sterols, nutrients and phospholipids and albumin.

Do not cook yolk.

Marbled Steak

2 lbs

Natural source of high quality protein & fat

Rarer is better

Salt cured Bacon

2 lbs

Natural source of fat.  Use the bacon fat to cook with – do not discard.

Avoid nitrates if possible.  High quality butchers use salt to cure meat.

Cream

1 Quart

Butyrate & good quality sterols.

Whipped cream is okay too.

Sour Cream

1-2 lbs

Butyrate & good quality sterols.

 

Onions

3 lbs

Clean carbohydrates & antioxidants

Cooked or raw

Potatoes

2-5 lbs

Clean carbohydrate source for citric acid cycle

 

Fresh/Frozen Berries

2 lbs

Natural anti-oxidant source and good taste.

Shop by color or Sam’s Club has 6 lb bags of fresh frozen berries.

Fresh Fruit

2 lbs

Anti-oxidants and complements to lipid diet

Shop by color and what looks good.  No white.  Eat raw.

Fresh Vegetables & fruit

10 lbs

Natural anti-oxidants, natural fiber, & flavor.

Shop by color pick what looks good to you.

Yogurt

1 quart

Natural source of acidophilus

NO ARTIFICIAL SWEETENERS

Maple Syrup or honey

½ quart

Natural source of polysaccharides and sweetener

Natural sweeteners are okay, strongly prefer diverse natural polysaccharides.

Prune Juice

1 gallon

Natural laxative

 

 

Recommended Kitchen Equipment

Spices and adjuncts

These aren’t essential, but they can help good tasting taste even better.

Foods to Avoid

Avoiding foods will be pretty easy because the list above will provide high quality calories for individuals.

If you’re hungry snack on yogurt, or fruit and berries with cream.

Bread is okay as long as you eat it with a lot of butter.  Use bread with a high fiber content. 

Avoid List

Reason

Vegetable Oils

Heat extraction ruins the fats.  Hexane residues are hepatic toxins.

Margarine

Pure source of trans fats.

Olestra

Source of unnatural bio-unusable lipids that do not contribute to healthy metabolism.

Artificial Sweeteners

NutraSweet & Aspartame degrade into formaldehyde, a lipophilic toxin

Junk food

Loaded with toxin of all sorts.

Carbohydrates without fat

Raw calories are

 

Supplement Strategy

This supplement strategy is designed to maximize absorption of phospholipids and to enable lipid bowel and skin clearance.

The pattern is simple.  Consume the phospholipid cocktail on

 

Meal

Consume

Waking

Phospholipid Cocktail

Breakfast

Yogurt

Lunch

Lipid Dense Meal

After Lunch

Fiber Cocktail

Dinner

Lipid Dense Meal

After Dinner

Fiber Cocktail

Bedtime

Lipid Snack

 

 

 

Definitions

Phospholipid Cocktail – put ½ cup of fresh/frozen fruit/berries in the blender.  If frozen add ½ cup of orange juice and blend or puree.  Use maple syrup, honey or a small amount of sugar if additional sweetness is desired.  Stop blender.  Add phospholipid supplement to the mixture and stir.  DO NOT BLEND THE PHOSPHOLIPIDS.  Blending will damage the structure and decrease the effectiveness.

The following table provides for a gradual increase in phospholipid supplementation.  If you get anything more than mild detoxification symptoms, do not increase the phospholipid intake.  Stay at the same level until the symptoms are gone.

 

Amount

Time

Level 1

1 Tablespoon

Minimum two days

Level 2

2 Tablespoons

Minimum two days

Level 3

3 Tablespoons

Minimum two days

Level 4

4 Tablespoons

Minimum two days

Level 5

6 Tablespoons

As long as needed

Incremental dosing helps avoid detoxification overload.  Generally, toxins released by diluting cellular lipids will enter normal lipid cycle. 

The phospholipid cocktail is taken in the morning.  Most of these phospholipids go directly to the liver cells and integrate within a few hours.  Integration will trigger a gradual release of polluted lipids.  The polluted lipids will be converted into bile and stored in the gall bladder until the next meals, lunch and dinner.

Yogurt. You can buy whole-fat yogurt from the grocery store.  Flavored varieties are fine as long as they don’t say: “LOW FAT”.  Also, be sure to check the ingredients to make sure they DON’T say “NutraSweet, aspartame, sorbitol, or any other artificial sweetener”.

 Yogurt is a fermented from milk using with acidophilus and organisms that support digestion.  The yogurt will help to maintain digestion and nutrient absorption for individuals with compromised digestion.  It provides a wide range of high quality nutrients also.

Lipid Dense Meal – The lipid dense meals are high in fats.  The recipes below have suggestions for lipid dense meals.  These meals are satisfying for most people.

The purpose of the high-fat meals is twofold:

Fiber Cocktail.  The fiber cocktail contains soluble fiber which bulks in the gut. 

The fiber cocktail is made of prune juice and soluble fiber.  Pour 4-8 ounces of prune juice in a glass and stir in two tablespoons of psyllium fiber.  Drink quickly before the mixture thickens.  If diarrhea results, reduce the prune juice to 4 ounces.

The cocktail serves two purposes:

Lipid Snack.  The lipid snack is bowl of fruit with cream or whipped cream.  Fruit with high quality ice cream like Hagen Daas, Breyers, or other ice cream devoid of artificial sweeteners is acceptable.

The lipid snack is designed to give a final bile release and help sleep. 

Recipes

 

 

 

Eggnog

1 dozen eggs; 2 cups cream; 3 Tbsp maple syrup; 1 Tsp nutmeg;

Put ingredients into blender and blend gently for 30 seconds, or until thickened.  Do not blend excessively or the cream will become butter.

Bacon & Potatoes

1 pound bacon; 1 large onion; 2-4 potatoes

Fry bacon leave fat in pan.  Cut onion into medium sized pieces,  Cut potato into medium sized pieces (baked potatoes work better) add onion and potato to pan and fry in bacon fat.

Steak

1 nice steak

Sprinkle with salt and pepper.  Grill or fry.  Rare is better.  Eat as much of the fat as you can

Baked Potato

& garlic

Medium sized potato.

Put washed potato in oven at 425.  Do not wrap in foil.  Cook for 35 minutes.  For faster cooking put a metal butter knife through the middle of the potato and cook with the knife inside the potato.  The knife carries the heat inside the potato.

Bake the garlic bulb, unpeeled, with the potato.  When done cooking remove the peeling and eat the garlic as a vegetable.

Eat the potato with at least ½ stick of butter and as much sour cream ¼ cup of sour cream.  

Eggs

3+ for a meal

Put eggs in a skillet and cook until whites are solid.  Yolk should be liquid.  The phospholipids in the yolk are more beneficial when uncooked.

Berry/Fruit Dessert

1 cup Berries ¼- ½ cup heavy cream

Put berries/fruit in a bowl and pour on cream.  Add honey or maple sugar to taste.

Whipped Cream

Put ½ cup cream;

1 Tablespoon sugar

1 teaspoon vanilla

Put cream, sugar, and vanilla in a metal bowl and blend with a wisk or hand mixer.  Pay attention because if you blend it too much you’ll get sweet butter.

If you get sweet butter, then you can use it with bread.

 

Supplement Support

There are a wide range of supplements which may help this program.  Generally speaking, any sort of detoxification program should be delayed until after the obvious symptoms associated with lipophilic toxins are gone.

Overdoing detoxification without the high-lipid turnover makes most people pretty sick.  You may want to use a conventional detox program to see how toxic you still are by starting at about 10% the recommended dosages and working your way up over a period of ten days. 

Other strategies that may be helpful:

Adjunct

Purpose

Bile Path Flush

To clear bile path.  Very important for success

Milk Thistle

Helps with liver cell turnover and protects regenerated cells from toxins

B-12

When oxygen transport is deficient, low Saliva pH

B-6

When Urine pH is higher than Saliva pH

Glutathione

To protect liver cells from oxidative damage and bind released toxins

Lipoic Acid

Lipophilic & Hydrophilic antioxidant

Vitamin C

To bind hydrophilic toxins that may release during cleanse

Digestive enzymes

To improve digestion caused by liver/pancreas dysfunction

Bile Flow Aids

Thin bile and improve detoxification process

Betaine / HCl

Enhance stomach acid to aid digestion and prevent reflux

 

Expectations

This is a complicated subject.  Here are a handful of things you may experience during this process:

Alerts & Suggestions

If you start to feel sick then do not increase any levels. 

If you feel like you’ve been on the program a long time and want to take a break, that’s okay.  Take a day off, but be sure to get back on the program tomorrow.